{"id":10695,"date":"2024-04-24T17:35:48","date_gmt":"2024-04-24T17:35:48","guid":{"rendered":"https:\/\/topat10.com\/?p=10695"},"modified":"2024-04-24T17:35:48","modified_gmt":"2024-04-24T17:35:48","slug":"doctors-combined-a-heart-pump-and-pig-kidney-transplant-in-breakthrough-surgery","status":"publish","type":"post","link":"https:\/\/topat10.com\/?p=10695","title":{"rendered":"Doctors Combined a Heart Pump and Pig Kidney Transplant in Breakthrough Surgery"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<p>A 54-year-old New Jersey woman has become the second living person to receive a genetically engineered pig kidney. The surgery, carried out at NYU Langone Health on April 12, also involved transplanting the pig\u2019s thymus gland to help prevent rejection.<\/p>\n<p class=\"paywall\">The patient, Lisa Pisano, had a mechanical heart pump implanted days before getting the transplant. She was facing heart failure and end-stage kidney disease and wasn\u2019t eligible for a human organ transplant because of several other medical conditions. Her medical team says she\u2019s recovering well.<\/p>\n<p class=\"paywall\">\u201cI feel fantastic,\u201d Pisano said from her hospital bed over Zoom during a press conference on Wednesday. \u201cWhen this opportunity came, I said, \u2018I\u2019m gonna take advantage of it.\u2019\u201d<\/p>\n<p class=\"paywall\">It\u2019s the first instance of a patient with a mechanical heart pump receiving an organ transplant of any kind. It is the second known transplant of a gene-edited pig kidney into a living person, and the first with the pig\u2019s thymus combined.<\/p>\n<p class=\"paywall\">The series of procedures was performed over a span of nine days. In the first, surgeons implanted the heart pump, a device called a left ventricular assist device, to replace the function of her failing heart. It\u2019s used in patients who are awaiting heart transplantation or otherwise aren\u2019t a candidate for a heart transplant. Without it, Pisano\u2019s life expectancy would have been just days or weeks.<\/p>\n<figure class=\"AssetEmbedWrapper-eVDQiB byBkf asset-embed\">\n<div class=\"AssetEmbedAssetContainer-eJxoAx dBHGoQ asset-embed__asset-container\"><span class=\"SpanWrapper-umhxW kGxnNB responsive-asset AssetEmbedResponsiveAsset-cXBNxi eCxVQK asset-embed__responsive-asset\"><picture class=\"ResponsiveImagePicture-cWuUZO dUOtEa AssetEmbedResponsiveAsset-cXBNxi eCxVQK asset-embed__responsive-asset responsive-image\"><noscript><img decoding=\"async\" alt=\"Close up of surgeon working on organ transplant\" class=\"ResponsiveImageContainer-eybHBd fptoWY responsive-image__image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_1600%2Cc_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg\" data-sizes=\"auto\" data-srcset=\"https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_120,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 120w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_240,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 240w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_320,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 320w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_640,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 640w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_960,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 960w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_1280,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 1280w, https:\/\/media.wired.com\/photos\/66290e134d07e6bc80cc0f37\/master\/w_1600,c_limit\/WI-0424-08-Animal-Human-Transplant-Photograph-2.jpg 1600w\" sizes=\"100vw\"\/><\/noscript><\/picture><\/span><\/div>\n<p><span class=\"BaseWrap-sc-gjQpdd BaseText-ewhhUZ CaptionCredit-ejegDm iUEiRd jTWYmb fNaHcW caption__credit\">PHOTOGRAPH: JOE CARROTTA FOR NYU LANGONE HEALTH<\/span><\/p>\n<\/figure>\n<p class=\"paywall\">The second surgery involved transplanting the pig organs. The animal\u2019s thymus gland, which is responsible for educating the immune system, was placed under the covering of the kidney. The addition of the pig thymus is meant to reprogram Pisano\u2019s immune system to be less likely to reject the kidney and hopefully allow doctors to reduce the amount of immunosuppressive drugs she has to take, said Robert Montgomery, director of NYU Langone\u2019s Transplant Institute, during the press conference.<\/p>\n<p class=\"paywall\">It\u2019s the latest attempt to transplant an animal organ in a person\u2014a process known as xenotransplantation\u2014as a potential way to address the organ shortage and offer transplants to people who otherwise wouldn\u2019t get them. In the US alone, there are more than 100,000 people on the national transplant waiting list, and every day 17 people die waiting for an organ. Strict eligibility criteria means that organs are prioritized for relatively healthy patients, leaving patients like Pisano with few other options.<\/p>\n<p class=\"paywall\">Starting in 2021, the NYU team began experimenting with transplanting genetically engineered pig hearts and kidneys into deceased humans following brain death. With the consent of their families, the patients were kept on a ventilator so that researchers could assess the viability of the pig organs. In one instance, a pig kidney was able to <a data-offer-url=\"https:\/\/nyulangone.org\/news\/two-month-study-pig-kidney-xenotransplantation-gives-new-hope-future-organ-supply\" class=\"external-link\" data-event-click=\"{&quot;element&quot;:&quot;ExternalLink&quot;,&quot;outgoingURL&quot;:&quot;https:\/\/nyulangone.org\/news\/two-month-study-pig-kidney-xenotransplantation-gives-new-hope-future-organ-supply&quot;}\" href=\"https:\/\/nyulangone.org\/news\/two-month-study-pig-kidney-xenotransplantation-gives-new-hope-future-organ-supply\" rel=\"noopener\" target=\"_blank\">function in a human body for up to two months<\/a>\u2014a record for xenotransplantation. In monkeys, pig kidneys have been shown to <a href=\"https:\/\/www.wired.com\/story\/a-monkey-got-a-new-kidney-from-a-pig-and-lived-for-2-years\/\">work for up to two years<\/a>. Now, scientists are testing whether they can support humans in need of new kidneys.<\/p>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>A 54-year-old New Jersey woman has become the second living person to receive a genetically engineered pig kidney. The surgery, carried out at NYU Langone Health on April 12, also involved transplanting the pig\u2019s thymus gland to help prevent rejection. The patient, Lisa Pisano, had a mechanical heart pump implanted days before getting the transplant. [&hellip;]<\/p>\n","protected":false},"author":364,"featured_media":10696,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[703],"tags":[1707,1706,1813,181,1538,1703,890],"class_list":["post-10695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology","tag-animals","tag-biotech","tag-diseases","tag-health","tag-medicine","tag-organ-transplants","tag-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Doctors Combined a Heart Pump and Pig Kidney 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Mullin","author_link":"https:\/\/topat10.com\/?author=364"},"uagb_comment_info":0,"uagb_excerpt":"A 54-year-old New Jersey woman has become the second living person to receive a genetically engineered pig kidney. The surgery, carried out at NYU Langone Health on April 12, also involved transplanting the pig\u2019s thymus gland to help prevent rejection. The patient, Lisa Pisano, had a mechanical heart pump implanted days before getting the transplant.&hellip;","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/posts\/10695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/users\/364"}],"replies":[{"embeddable":true,"href":"https:\/\/topat10.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10695"}],"version-history":[{"count":0,"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/posts\/10695\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/topat10.com\/index.php?rest_route=\/wp\/v2\/media\/10696"}],"wp:attachment":[{"href":"https:\/\/topat10.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/topat10.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/topat10.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}